First Response™

What Exactly Is LH?

Your menstrual cycle has three phases. In each of these phases the body produces different hormones that have distinct functions. The first phase of your cycle is called the follicular phase. This begins on Day one of your cycle, which is the first full day of menstrual bleeding when the lining of the uterus starts to shed. When an egg isn't fertilized during the previous cycle, the body must shed the uterine lining to prepare for the next cycle. For most women this lasts from 3 to 5 days, but can be more or less. Immediately following the shedding of the uterine lining, your body begins to prepare for the next phase in the cycle, the ovulatory phase.

But first, hormones must prepare your body for ovulation before this phase can begin. The pituitary gland releases two hormones, FSH (Follicle Stimulating Hormone) and LH (Luteinizing Hormone). A follicle is one of the many tiny sacs within an ovary that contains a developing egg. FSH stimulates a follicle to grow and the egg within it to ripen. LH stimulates the follicle to manufacture and secrete estrogen.

You're in the ovulatory phase now, increasing estrogen levels cause the lining of the uterus to re-nourish with nutrients and blood. The heightened levels of estrogen also produce a change in cervical mucus, causing it to thin and take on a slippery consistency. The change in cervical fluid makes it easier for sperm to make their way toward a waiting egg. All of this usually takes place between days 7 and 11 in a woman's cycle.

When the amount of estrogen produced in your body reaches a certain level, it causes the pituitary gland to release a surge of LH. 24 to 36 hours after the LH surge, the follicle will burst, releasing the completely ripened egg into the Fallopian tube. The LH surge is what triggers the almost-ripened egg to become fully matured and break through the follicle. The release of the egg is what is known as ovulation.

The liberated egg now floats down the fallopian tube toward the womb. If it isn't fertilized, it has a survival window of about 24 hours. Sperm can live longer and may already be present before the egg is released. Or sperm may arrive in the 24 hours after the egg has been released. Therefore, the day before ovulation and the day of ovulation are the two days in your cycle when you are most fertile — the two days you are most likely to conceive. Since the LH surge always precedes ovulation, detecting this hormone is critical in predicting your two peak fertility days. The
FIRST RESPONSE™ Ovulation Test and FIRST RESPONSE™ Daily Digital Ovulation Test are over 99% accurate (in laboratory testing) in detecting the LH surge in your urine.

Next, the follicle in which the egg burst through (called the corpus luteum) starts to shrink and begins to release progesterone and estrogen. Progesterone further prepares for a fertilized egg by building the lining of the womb with an increase in blood vessels.

The final and third phase of your menstrual cycle is called the luteal phase and follows ovulation. If the egg is fertilized, hCG is produced by the body and pregnancy tests are designed to detect it. hCG keeps the follicle from shrinking completely so it can continue to produce progesterone and estrogen. The increased production of progesterone keeps the uterus intact so that the fertilized egg — the pregnancy — is maintained.

If the egg is not fertilized within 24 hours, the corpus luteum dies and progesterone production slows. When there is no longer enough progesterone to supply the uterine lining with blood, after around 11-14 days, the start of your period — your menstrual cycle — begins again.

For extensive information and support for those trying to conceive, visit

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