Semaglutide & Pregnancy: What to Know About Weight Loss While Pregnant or Trying to Conceive

If you’re taking a semaglutide medication like Ozempic® or Wegovy® and thinking about starting a family (or just got that surprise positive test!), you’re not alone. As more people use GLP-1 medications like Ozempic® and Rybelsus®, questions around fertility, pregnancy, and postpartum planning are becoming more common. While these medications may not influence fertility directly, the lifestyle changes they support, like weight loss or improved insulin sensitivity, may play a role in reproductive health.

Whether pregnancy is on your mind now or further down the road, it’s worth understanding how these medications may fit into your plans.

What is Ozempic®?

Ozempic® is a prescription medication primarily used to manage blood sugar levels in people with type 2 diabetes. It’s also approved to reduce the risk of serious cardiovascular events, like heart attack or stroke, in adults with both type 2 diabetes and heart disease.

Ozempic® belongs to a class of drugs known as GLP-1 receptor agonists. These medications have gained attention for their role in improving blood sugar control and supporting weight loss. While originally developed for diabetes management, several GLP-1s are now being prescribed at higher doses to help treat obesity.

Research has shown that GLP-1 medications are associated with modest weight loss. However, about 1/3 of patients can lose greater than 5% of the body weight.

Does Ozempic® Affect Fertility?

Semaglutide medications, such as Ozempic®, Wegovy®, or Rybelsus®, do not directly affect fertility, but emerging research has found they may help improve it among women with polycystic ovary syndrome (PCOS) by improving insulin sensitivity and metabolic outcomes. For those whose reproductive health is impacted by PCOS, these changes may increase the chance of conceiving.

What is an “Ozempic Baby”?

“Ozempic babies” refers to unexpected pregnancies while taking GLP-1 medications, such as Ozempic® or Wegovy®. While there are anecdotal reports on social media about surprise pregnancies while on GLP-1s, the jury is still out. For now, “Ozempic babies” appear to be more of an online conversation than a documented outcome.

Does Ozempic® Make Birth Control Less Effective?

Because every person’s health history and medication regimen is different, you’ll want to talk to your healthcare provider about how your meds may interact with birth control pills.

Can You Take Ozempic® While Trying to Get Pregnant?

If you’re currently taking a GLP-1, such as Ozempic®, and trying to conceive, it’s important you talk to your healthcare provider as they can guide you through this process. Planning a pregnancy while on medication can be complex, and your healthcare team can help you understand your options and create a plan that’s right for you.

What If I Get Pregnant While Taking Ozempic®?

If you think you might be pregnant while taking a GLP-1, take the guesswork out with FIRST RESPONSE™. Try the FIRST RESPONSE™ Early Result Pregnancy Test to find out 6 days sooner than your missed period¹, or go for the FIRST RESPONSE™ Rapid Result Test for results in just one minute on the day of your missed period.

If you have a positive pregnancy test, or believe you are pregnant, talk to your healthcare provider right away. They can advise you on next steps and help ensure you get the care you need. The first few weeks of pregnancy are critical to fetal development, making early prenatal care important for you and your baby.

Healthy Habits for Pregnancy (and Beyond)

Adopting healthy habits supports fertility, pregnancy, and overall well-being. Whether planning for pregnancy or simply living your best life, small changes can make a lasting impact. Here’s where to focus:

• Prioritize protein and healthy fats to nourish your body and support fetal development
• Load up on fruits and veggies as they’re packed with essential vitamins, minerals, and fiber
• Choose nutrient-rich foods and drinks, such as those high in folate, iron, calcium, and protein. Ask about prenatal vitamins to cover any gaps
• Stay hydrated and include plenty of fiber in your diet to prevent constipation
• Engage in moderate exercise each week (unless otherwise advised by your provider)

These simple changes not only help promote a healthy pregnancy but also pave the way for a smoother postpartum recovery.

Navigating Pregnancy & GLP-1s

To wrap it up, Ozempic® and other GLP-1 medications aren’t made to boost fertility but may offer some reproductive benefits for women with PCOS. If pregnancy is on your mind (or suddenly in your reality), talk with your healthcare provider about the best path forward for your body and your goals. Whether you’re planning, preventing, or just staying informed, understanding how these meds fit into the picture helps you make empowered choices that feel right for you.